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Synopsis
A fading celebrity decides to use a black market drug, a cell-replicating substance that temporarily creates a younger, better version of herself.
Title | The Substance |
Companies | Working Title Films, Blacksmith, Working Title Films |
Countries | France, United Kingdom, United States of America |
Keywords | new year's eve, capitalism, black market, identity, beauty, satire, aging, celebrity, female protagonist, los angeles, california, has been, aerobics, disfigurement, woman director, disturbed, beauty standards, insecure woman, toxic masculinity, drug, body horror, youth, actress, distressing |

Demi Moore
Elisabeth
Margaret Qualley
Sue
Dennis Quaid
Harvey
Gore Abrams
Oliver
Oscar Lesage
Troy
Christian Erickson
Man at Diner
Robin Greer
Male Nurse
Tom Morton
Doctor
Hugo Diego Garcia
Diego - Boyfriend
Daniel Knight
Casting Director
Jonathon Carley
Assistant Casting Director
Jiselle Henderkott
Girl Auditioning / New Year's Eve Show Dancer
Akil Wingate
TV Host
Vincent Colombe
Man in Suit #1 - Harvey's Office
Billy Bentley
Man in Suit #2
Lennard Ridsdale
Man in Suit #3
Jordan Ford Silver
Assistant Director - Pump It Up Show
Oscar Salem
2nd Assistant Director - Pump It Up Show
Viviane Bossina
Sue's Assistant
Matthew Luret
Floor Runner
Jana Bittnerová
Maria
Olivier Raynal
Alan - 2nd Agent
Tiffany Hofstetter
StylistNicolas Royer
Guy in the Elevator
Nathan Rippy
Assistant Director - New Year's Eve ShowManon Arizmendi
Little Girl - New Year's Eve Show
Virginie Kotlinski
Mother - New Year's Eve ShowBrett Gillen
Director of Photography - New Year's Eve Show
Charlotte Marquardt
Screaming Woman
Léa Hengl
Screaming Woman
Gaëlle Raymond
Screaming WomanClaire Lemaire
Screaming Woman
Lila Boughoufala
Screaming Woman
Aurélien Lorgnier
Screaming Man
Ivan Sellier
Screaming Man
Philip Schurer
Screaming Man
Christian Bourmier
ShareholderMartin Graham
Shareholder
Christian Bordeleau
Shareholder
Patrick Hamel
ShareholderDidier Dhondt
ShareholderJacques-Yves Dorges
ShareholderJean-Claude Matthey
ShareholderOlivier Jarcin
Shareholder
Jean-Luc Magneron
ShareholderCharlotte Murray
Allison - Diner WaitressAaron Kahn
Greeting PersonGabriela Arnon
Greeting PersonNancy Josephson Lahoussine
Greeting Person
Andrew Eldridge
Greeting Person
Denise Powers
Greeting PersonBryan Jones
Greeting Person
Adam Carage
Happy Birthday Person
Maria McClurg
Happy Birthday Person
Andrew Desmond
Happy Birthday PersonRebecca Lafont
Happy Birthday Person
Laura Puech
Isabella
Ryan Chidester
Stagehand
Céline Vogt
Elisabeth (Young) - Walk of Fame
Yannick Guérin
Clumsy Burger Guy - Walk of FameJean Miel
Worker Walk of FamePaul Descoings
Worker Walk of FameBenoit Lévêque
Worker Walk of FameArthur Molinet
Cocktail BartenderManon Sachot
Cocktail Lounge CoupleBastien Jorelle
Cocktail Lounge CoupleKelly Hoarau
Female Assistant - TowelMichel Juskiewicz
George - Harvey's Friend
Louise Greggory
Restaurant WaitressChristophe Sartirano
Guy Looking at SueFlorent Torres
Guy Looking at SueRomain Caldeira
Billboard TechnicianBarthelemy Thomas
Billboard TechnicianAxel Baille
Photographer
Ashley Lambert
Additional Voices (voice)
Ranjani Brow
Additional Voices (voice)Chase Fein
Additional Voices (voice)
Shane Sweet
Additional Voices (voice)William Calvert
Additional Voices (voice)
Michael Corbett
Additional Voices (voice)
Stephen Apostolina
Additional Voices (voice)
Yann Bean
The Substance (voice)Audjyan Alcide
Pump It Up Show DancerJonathan Jenvrin
Pump It Up Show DancerMimi Maury
Pump It Up Show DancerAmelye Solange
Pump It Up Show DancerKévin Table
Pump It Up Show DancerLaura Boera
Sparkle Your Life Show DancerCissy Duc
Sparkle Your Life Show DancerSophie Mercier
Sparkle Your Life Show DancerMarie Valton
Sparkle Your Life Show DancerKatrina Budzynski
New Year's Eve Show DancerAlicia Maury
New Year's Eve Show DancerMegane Adamik
New Year's Eve Show DancerAnnalisa Pagnotta
New Year's Eve Show DancerMaelle Dantigny
New Year's Eve Show DancerAleksandra Fontaine Kedzierska
New Year's Eve Show DancerPauline Sagetat
New Year's Eve Show DancerAgustina Fitzsimons
New Year's Eve Show DancerElena Shcheglova
New Year's Eve Show DancerEve Marchant
New Year's Eve Show DancerLola Donati
New Year's Eve Show DancerKate Matthews
New Year's Eve Show DancerOphélie Jonard
New Year's Eve Show DancerPauline Richard
New Year's Eve Show DancerLaureen Cappelliez
New Year's Eve Show Dancer
Daria Panchenko
New Year's Eve Show DancerDelphine Beaulieu
New Year's Eve Show DancerVictoria Brun
New Year's Eve Show DancerCara Chapman
New Year's Eve Show DancerKatharine Matthews
New Year's Eve Show DancerAlexandra Faget
New Year's Eve Show DancerClémence Juville
New Year's Eve Show DancerMargot L'Entete
New Year's Eve Show DancerHillary Sukhonos
New Year's Eve Show Dancer
Matthew Géczy
Bob Haswell (uncredited)
Namory Bakayoko
Silhouette (uncredited)
Gregory Defleur
Happy Birthday Person (uncredited)